Transcriptomic Similarity Mapping and Knowledge Graph Embeddings: Computational Strategies for Systematic Drug Repurposing
Keywords:
transcriptomic similarity mapping, knowledge graph embeddings, computational strategies, systematic drug repurposing, machine learningAbstract
Drug repurposing focuses on identifying novel therapeutic indications for existing drugs, currently marketed for other diseases, and has several advantages over traditional de novo drug discovery. Repurposing is both time and cost-efficient, allowing faster drug development by one to two years, with R&D costs reduced by 60% when compared to novel drug development, and can bring drugs for new indications to the market at a reduced cost of $30–40 million.Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
License Terms
Ownership and Licensing:
Authors of this research paper submitted to the journal owned and operated by The Science Brigade Group retain the copyright of their work while granting the journal certain rights. Authors maintain ownership of the copyright and have granted the journal a right of first publication. Simultaneously, authors agreed to license their research papers under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License.
License Permissions:
Under the CC BY-NC-SA 4.0 License, others are permitted to share and adapt the work, as long as proper attribution is given to the authors and acknowledgement is made of the initial publication in the Journal. This license allows for the broad dissemination and utilization of research papers.
Additional Distribution Arrangements:
Authors are free to enter into separate contractual arrangements for the non-exclusive distribution of the journal's published version of the work. This may include posting the work to institutional repositories, publishing it in journals or books, or other forms of dissemination. In such cases, authors are requested to acknowledge the initial publication of the work in this Journal.
Online Posting:
Authors are encouraged to share their work online, including in institutional repositories, disciplinary repositories, or on their personal websites. This permission applies both prior to and during the submission process to the Journal. Online sharing enhances the visibility and accessibility of the research papers.
Responsibility and Liability:
Authors are responsible for ensuring that their research papers do not infringe upon the copyright, privacy, or other rights of any third party. The Science Brigade Publishers disclaim any liability or responsibility for any copyright infringement or violation of third-party rights in the research papers.
